Wellbutrin SR (bupropion) is an antidepressant used to treat depression, seasonal affective disorder (SAD), and as a smoking-cessation aid.

The medication is a norepinephrine and dopamine reuptake inhibitor (NDRI) which, while widely used in some areas, is not prescribed for depression as often as selective serotonin reuptake inhibitors (SSRIs). Both NDRIs and SSRIs produce similar results in elevating mood, but SSRIs work by increasing levels of serotonin while NDRIs work by increasing levels of dopamine.

Wellbutrin Options

Patients planning to buy Wellbutrin SR should note that there are several versions of Wellbutrin, which should not be used interchangeably:

• Wellbutrin immediate-release tablets are taken 1 to 3 times per day. Effects last around 6 hours, and doses should be taken at least 6 hours apart.
• Wellbutrin SR (sustained-release) is usually taken 2 times per day. Effects last around 12 hours and doses should be taken at least 8 hours apart.
• Wellbutrin XL (extended release) is usually taken once per day. Effects last around 24 hours and doses should be taken 24 hours apart.
• Zyban is a brand name marketed as a smoking cessation aid. Zyban is essentially the same as Wellbutrin SR; it is taken 2 times per day with at least 8 hours between doses.

Because the different forms of Wellbutrin release the medication at varying speeds, taking the wrong type of tablet on a dosing schedule designed for a different type of tablet will at a minimum disrupt treatment, and could potentially lead to serious adverse effects if too much medication is ingested.

Wellbutrin SR for Depression

The vast majority of Wellbutrin SR use is in treating depression. The medication has several advantages over the more-commonly prescribed SSRI antidepressants:

• Reduced risk of sexual side effects such as loss of libido or impotence;
• Reduced risk of the weight gain associated with SSRIs;
• Reduced risk of physical or psychological addiction;
• Increased likelihood of alleviating depression-related fatigue or anxiety.

As mentioned above Wellbutrin SR is typically taken twice per day, while the XL version is once per day and immediate-release tablets may be taken up to 3 times per day. The decision to buy Wellbutrin SR, XL or immediate-release tablets is very often a matter of patient preference, though a doctor may advise a particular type in individual cases.

In all cases treatment generally starts with several days of lower doses; for example, 150 mg may be taken once daily for three days, then increased to the long-term dose of 150 mg twice daily.

The standard dose of Wellbutrin SR for most patients is 300 mg per day, divided into two 150 mg doses. If 300 mg is not effective after several weeks of treatment, dosage may be increased to 400 mg per day, given in two 200 mg doses. Never exceed 200 mg of Wellbutrin SR in a single dose, or 400 mg in one day.

Wellbutrin SR for Smoking Cessation

Many patients buy Wellbutrin SR as a smoking cessation aid; though the medication is marketed as Zyban for this purpose, Wellbutrin SR is essentially the same product.

The medication helps break the smoking habit in several ways:

• Reduces cravings for nicotine;
• Minimizes withdrawal symptoms;
• Reduces the pleasurable effects of smoking.

Like use in depression, treatment typically starts at lower doses for several days and is then increased to 150 mg twice daily, for a total daily dose of 300 mg per day. Treatment should begin two weeks prior to actually quitting, and typically continues for at least 8 weeks.

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